解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::As a continuation of our study, physicochemical properties of some antibacterial active 4-imino-1,4-dihydrocinnoline-3-carboxylic acid and 4-oxo-1,4-dihydrocinnoline-3-carboxylic acid derivatives were investigated. Partition coefficient (log P), and dissociation constant (pKa) were experimentally determined and also c...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2007-05-01 00:00:00
abstract::The influence of tiagabine at a dose of 3.2 mg/kg (single administration) and at a dose of 1.2 mg/kg (multiple administration - 10 days) on the antinociceptive effect of morphine (10 mg/kg), metamizole (500 mg/kg) and indomethacin (10 mg/kg - single dose and 1.4 mg/kg - multiple doses) was investigated in mice using t...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2007-05-01 00:00:00
abstract::A DNA-binding affinity and the effect on restriction enzymes activity of seven carbocyclic mono- and bis-lexitropsins and two analogues of pentamidine with unsubstituted N-terminal amine group were investigated. DNA association constants (Kapp) show that DNA affinity of mono-compounds is much weaker than netropsin and...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2007-03-01 00:00:00
abstract::To obtain rich in organic forms of zinc extracts of Lentinus edodes, possessing putative higher immunostimulating properties than actually used, mycelia were cultivated in zinc(II) enriched media. Culture media were enriched in zinc in concentration ranging from 0 to 90 microg mL(-1), added to the medium before inocul...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::The aim of this study was to prepare and evaluate microspheres containing ibuprofen. Microspheres were prepared by modified quasi-emulsion solvent diffusion method. The influence of formulation factors (drug-polymer ratio, volumes of solvent, polyvinyl alcohol concentration and type of polymer) on the morphology, part...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2006-11-01 00:00:00
abstract::3-Hydroxy-3-methyl-glytaryl coenzyme A (HMG-CoA) reductase inhibitors ("statins") have been proved to be extremely useful in the management of hypercholesterolemia, as well as in prevention of primary and secondary coronary heart disease. However, they may produce rare but severe muscle-related symptoms such as myopat...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2006-09-01 00:00:00
abstract::3-(Oxiran-2-ylmethoxy)-l ,5-diphenyl-lH-1,2,4-triazole [I] was obtained in the reaction of 1,5-di-phenyl-IH-1,2,4-triazol-3-ol with 2-(chloromethyl) oxirane. Then I was converted into the corresponding aminoalkanol derivatives of 1,5-diphenyl-IH-1,2,4-triazol-3-ol, IIa,b -VIIa,b. Molecular structure of I was confirmed...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2006-07-01 00:00:00
abstract::An aim of the study was to determine the protein expression of the FAS-related apoptosis signaling pathway (FADD-FAS Associating Protein with Death Domain, PRO-CASPASE-8 and CASPASE-8), which are responsible for signal transduction to trigger programmed cell death (apoptosis) in cancer and Prostatic Intraepitelial Neo...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2006-07-01 00:00:00
abstract::A procedure for simultaneous determination of metoprolol and hydrochlorothiazide in tablets by employing derivative spectrophotometry, "zero-crossing" method was developed. The third order derivative absorption spectra at lambda approximately 281 nm were used for metoprolol and the first order derivative spectra at la...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2006-05-01 00:00:00
abstract::Pyrenacantha staudtii is a medicinal plant used widely in the West African sub-region particularly in Nigeria for the treatment of threatened abortion and dysmenorrhea. This study reports for the first time the chemical isolation and characterization of 3-carbomethoxypyridine from one of the active fractions of the me...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2006-05-01 00:00:00
abstract::Alkoxyacetic acids (AAAs) are known urinary metabolites of the corresponding ethylene glycol monoalkyl ethers with a wide range of industrial and domestic applications. Hemolysis is the principal toxic effect of AAAs in humans and animals. The mechanism of red-cell damage is not known. It is suggested that some distur...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2006-03-01 00:00:00
abstract::The etiology of the interstitial cystitis (IC) is believed to be a dysfunction of the bladder glycosaminoglycan (GAG) protective layer of the urothelial cells. Management of interstitial cystitis (IC) is pure empirical. The aim of this study was to establish primary rabbit urothelial cells (PRUCC) affinity to complex ...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2006-03-01 00:00:00
abstract::Floating matrix tablets are designed to prolong the gastric residence time after oral administration, at a particular site and controlling the release of drug especially useful for achieving controlled plasma level as well as improving bioavailability. With this objective, floating dosage form containing clarithromyci...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::The effect of -CF3 R2 fluphenazine (FLF) and -Cl R2 perphenazine (PF) substituents on interactions of these phenothiazine derivatives with cyclodextrins (CD) was compared. Inclusion complexes of protonated and basic forms of FLF and PF with CDs were obtained in HCl 0.01 mol/L (pH 1.9 or 2.1), in phosphate buffer (pH 5...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2005-11-01 00:00:00
abstract::The study "Alexander" on bacterial resistance to antibiotics conducted in Poland revealed high sensitivity of bacterial strains to simple and cheap antibiotics. In Poland pharmacoeconomic studies on the safety, effectiveness and costs of treatment are rare. Development of therapeutic standards in bacterial infections ...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2005-11-01 00:00:00
abstract::Three rapid, simple and accurate analytical methods for the determination of citalopram in tablets were developed. The capillary zone electrophoresis (CZE) method was carried out using fused silica capillary with 67 mM phosphate buffer pH 7.0 as the background electrolyte, 30 kV of separation voltage and UV detection ...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2005-09-01 00:00:00
abstract::Piracetam (2-oxo-1-pyrrolidine-acetamide), the most common of the nootropic drugs, is a cyclic derivative of gamma-aminobutyric acid. The treatment with piracetam improves learning, memory, brain metabolism, and capacity. Piracetam has been shown to alter the physical properties of the plasma membrane by increasing it...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章,评审
doi:
更新日期:2005-09-01 00:00:00
abstract::The stability of cefuroxime axetil in BIORACEF tablets was studied by means of long term (298 K/60% RH), intermediate (303 K/65% RH), accelerated (313 K/75% RH) and stress stability tests. Changes in the concentration of cefuroxime axetil diastereoisomers A and B and their total was determined using the RP-HPLC method...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2005-05-01 00:00:00
abstract::Pyrimido[5,4-c]cinnoline and pyrimido[5,4-c]quinoline derivatives have been tested as potential intercalators. All of them embody stuctural properties alike to afford intercalating activity. Their cytotoxicity was determined on the two human leukemia cell lines, the promyelocytic HL-60 and the lymphoblastic NALM-6. Th...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2005-03-01 00:00:00
abstract::Orodispersible tablets, usually prepared using freeze-drying method, are becoming a popular drug formulation for patients who have difficulties swallowing solid dosage forms. The influence of drug solubility and concentration on the physical characteristics of lyophilized tablets composed of mannitol and gelatin was i...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::Abstract: In the search for inhibitors of the non-structural protein 3 (NS3)-associated NTPase/helicase activities of the hepatitis C virus (HCV), and of the related West Nile Virus (WNV), and Japanese Encephalitis Virus (JEV), random screening of a broad range of unrelated low-molecular weight compounds revealed that...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2004-12-01 00:00:00
abstract::Doxorubicin (DOX) is an anthracycline antibiotic with a potent anticancer activity used against human neoplasms. Doxorubicin causes numerous adverse effects i.e., toxic effect on the cardiovascular system of experimental animals and humans. DOX may provoke a few types of cardiomyopathies: an acute, subacute, chronic a...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2004-12-01 00:00:00
abstract::Structural and biological investigations on a new 7-amino-3,5-dimethylisoxazole [5,4e][1,3,4]-triazepin-4-one were performed. The compound was shown to stimulate concanavalin A-induced mouse splenocyte proliferation and cytokine production by macrophage P388D1 cell line. ...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2004-12-01 00:00:00
abstract::A series of N-phenyl-2-aza-spiro[4.5]decane-1,3-diones [III-VIIII] structurally related to the previously described N-phenyl-3-arylpyrrolidine-2,5-dione (11) was synthesized and tested for their anticonvulsant activity in the maximum electroshock seizure (MES) and metrazole seizure threshold (sc. MET) tests. The most ...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2004-11-01 00:00:00
abstract::Ocular inserts were developed with prolonged release of drug and minimum swelling within cul-de-sac using ciprofloxacin (CPF) hydrochloride as a model drug. The ocular inserts were fahricated with sodium alginate films loaded with drug and then treated with calcium chloride. A 4% w/v solution of calcium chloride and a...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2004-09-01 00:00:00
abstract::Tablets of salicylic acid (drug model) have been formed using two analogous acrylatemethacrylate copolymers designated here as A and B as binders. A and B differ only in their content of quaternary ammonium (cationic) groups in the ratio 2:1 (A:B). The aim was to investigate the effect of the cationic groups on the ta...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2004-07-01 00:00:00
abstract::A high-performance liquid chromatographic assay has been developed to the separation of angiotensin I, tetradecapeptide and the tetrapeptide Leu-Val-Tyr-Ser. This purpose is achieved in a single step, using HPLC technique in the reversed phase system. The method is based on enzymatic hydrolysis of a substrate renin (T...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2004-05-01 00:00:00
abstract::Human exposure to environmental pollution is of great interest nowadays. Many substances present in the environment are considered as carcinogenic to humans. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental carcinogens. In this paper, PAHs are described: their physicochemical properties, natural an...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章,评审
doi:
更新日期:2004-05-01 00:00:00
abstract::In this survey magnesium sails in the form of solid dispersions were studied to examine the interaction of the drug and lecithin or Tego Betain L-7. The results of thermal analysis of solid dispersions containing magnesium adipate Mg[Adip] and compounds of this salt with glycine substituent, and the partition coeffici...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2004-03-01 00:00:00
abstract::The antidepressant effect of ACEA (arachidonyl-2-chloroethylamide), a selective agonist of CB1 receptors, and its interaction with fluoxetine were studied in mice. ACEA (1.0 and 2.0 mg/kg i.p.) reduced the immobility time in the forced swimming test and attenuated the head - twitch response to L-5-HTP. The concomitant...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2004-03-01 00:00:00
abstract::The content of phenolic acids was determined in the extracts and fractions from leaves, flowers and fruits of Symphoricarpos albus (L.) Blake (Caprifoliaceae) by the Arnov's method. Antimicrobial activity of all extracts against Gram-positive anti Gram-negative microorganisms has been tested. ...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::The influence of temperature and relative humidity on the stability of cefetamet pivoxil (CFP) and its hydrochloride (CFP.HCl) in solid phase was investigated. The process of degradation was studied using HPLC with UV detection. The degradation of CFP and CFP.HCl occurring at air humidity RH>50% is an autocatalytic fi...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2003-11-01 00:00:00
abstract::Continuing our studies with the design of new anxiolytics we have now synthesized a series of new compounds, derivatives of 1-methoxybicyclo[2.2.2]-oct-5-one-2,3-dicarboximide bearing a 4-aryl-1-piperazinylbutyl group attached to the imide nitrogen. ...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2003-09-01 00:00:00
abstract::Kinetics of hydrolysis of S-methyl-2-thiophenobarbital in aqueous solutions was investigated using the UV spectroscopic method within the pH range 1.5-12.9 at 60 degrees C. Chromatography was used to separate and isolate the products of hydrolysis of this compound and its N-methyl isomer. The products were identified ...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2003-07-01 00:00:00
abstract::The qualitative analysis and quantitative determination of hydroquinone derivatives (arbutin, pyroside) in the flowers of naturally growing pear tree and of its four cultivated varieties (Pomarańczówka, Lukasówka, Klapsa, Salisbury) were carried out. The comparative qualitative analysis of hydroquinone derivatives was...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2003-07-01 00:00:00
abstract::The methanolic extract of both Cuscuta reflexa stem and Corchorus olitorius seed showed marked protection against convulsion induced by chemoconvulsive agents in mice. The catecholamines contained were significantly increased in the processed extract treated mice. The amount of GABA, which is most likely to be involve...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2003-05-01 00:00:00
abstract::The aim of this study was to investigate the stability of mycophenolic acid (MPA) in human plasma from patients receiving mycophenolate mofetil (MMF) therapy. MPA was measured using a validated HPLC method. MPA concentrations were determined immediately after receiving the samples in the laboratory, and after 24 h, 72...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2003-03-01 00:00:00
abstract::The reaction of 2-(beta-hydroxyethyl)-pyrrolidine with isothiocyanates gave rise to the formation of thiourea derivatives which cyclised on refluxing in hydrobromic acid to yield N-(3,4,4a,5,6,7-hexahydro-1H-pyrrolo[1,2-c][1,3]thiazin-1-ylidene)-aryl(alkyl)amines. The results of preliminary pharmacological screening a...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::The INH metabolism mainly involves acetylation to acetyloisoniazid by a non inducible hepatic enzyme N-acetyltransferase. Examples of drugs acetylated by this enzymatic system are: isoniazid, sulphadimidine. hydrallazine, dapson and sulphapyridine. The rate of acetylation is constant in any individual but varies in di...
journal_title:Acta poloniae pharmaceutica
pub_type: 临床试验,杂志文章
doi:
更新日期:2002-11-01 00:00:00
abstract::The derivatives of dibenzoxazocinone, dibenzoxadiazocine, dibenzoxadiazonine, and benzodiazepine systems were synthesized as potential lead compounds for inhibitors of HIV-1 reverse transcriptase. The suggested structures were derived from analysis of the described spatial and physicochemical requirements for HIV-1 RT...
journal_title:Acta poloniae pharmaceutica
pub_type: 杂志文章
doi:
更新日期:2002-09-01 00:00:00